SMB chromatography Process Flowsheets & Simulations
Explore 2 validated, solved SMB chromatography simulation flowsheets in MaximaLabs — real components: r_ibuprofen, s_ibuprofen, ethanol, fructose, glucose, water. Open any one directly in your browser.
Solved via: PENG-ROBINSON.
Chiral API purification: continuous SMB chromatography
A racemic active pharmaceutical ingredient (R/S enantiomers, dilute in ethanol eluent) is resolved continuously by simulated moving bed chromatography — the workhorse of chiral-drug manufacture that legacy steady-state flowsheet simulators have no native model for (engineers script it in MATLAB). This uses the native SMB unit op, which solves the standard steady-state True Moving Bed equivalent: a 4-zone counter-current equilibrium-stage cascade whose zone flow-rate ratios sit inside the triangle-theory separation region, so the more-retained enantiomer reports to the extract and the other to the raffinate — the separation is driven by the chiral adsorption selectivity (the two enantiomers are otherwise thermodynamically identical). Honesty note: this is the TMB steady-state equivalent, not the transient multi-column process with discrete port switching; stages are ideal equilibrium stages (no mass-transfer resistance / axial dispersion); the isotherm affinities are illustrative screening values.
5 unit ops • PENG-ROBINSON
19 0
View & openHigh-fructose corn syrup: SMB glucose/fructose separation
The single largest-volume industrial SMB in the world — separating fructose from glucose to make 55-HFCS. A glucose/fructose isomerate (dilute in water eluent) feeds the native SMB unit op; on a Ca²⁺-form ion-exchange resin fructose is the more-retained sugar, so it reports to the extract (the sweetener product) while glucose leaves in the raffinate (recycled to the isomerase reactor in a real plant). Solved as the steady-state True Moving Bed equivalent — a purely isotherm-driven liquid separation, so the sugars need no vapor-liquid-equilibrium data. Honesty note: TMB steady-state equivalent (not the transient port-switching process), ideal equilibrium stages, illustrative isotherm affinities capturing the real fructose > glucose retention order.
5 unit ops • PENG-ROBINSON
18 0
View & open