LNP formulation simulation

aqueous RNA + lipid in ethanol -> formulated suspension

Governing equations

The exact equations the solver works for a lnp formulation — the same math shown in the app's "Theory" panel, not a black box.

$N/P$

ionisable amines per RNA phosphate

$a$

amines per lipid molecule

$M_{lipid}$

lipid molar mass [kg/mol]

$M_{nt}$

molar mass per nucleotide [kg/mol]

$t_{mix}$

diffusive mixing time [s]

$\delta$

striation width [m]

$D$

diffusivity [m^2/s]

$\tau$

mixer residence time [s]

$V_{mixer}$

mixer volume [m^3]

$Q$

total volumetric flow [m^3/s]

Parameters

rna + lipid [component ids], rna_molar_mass + lipid_molar_mass [kg/mol — N/P is a molar ratio]. Optional: amines_per_lipid, organic_ethanol_fraction, striation_width [m] + mixer_volume [m^3] (turns on the mixing-vs-residence check), diffusivity [m^2/s]. Particle size is deliberately not predicted.