High-fructose corn syrup: SMB glucose/fructose separation — a PENG-ROBINSON process flowsheet
The single largest-volume industrial SMB in the world — separating fructose from glucose to make 55-HFCS. A glucose/fructose isomerate (dilute in water eluent) feeds the native SMB unit op; on a Ca²⁺-form ion-exchange resin fructose is the more-retained sugar, so it reports to the extract (the sweetener product) while glucose leaves in the raffinate (recycled to the isomerase reactor in a real plant). Solved as the steady-state True Moving Bed equivalent — a purely isotherm-driven liquid separation, so the sugars need no vapor-liquid-equilibrium data.
Modeling assumptions & limitations
- 1TMB steady-state equivalent (not the transient port-switching process), ideal equilibrium stages, illustrative isotherm affinities capturing the real fructose > glucose retention order.
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- Rigorous PENG-ROBINSON thermodynamics, solved by the same engine every simulation runs on.
- 1 unit operations modeled: SMB.
- Focus areas: SMB chromatography, HFCS, Sugar separation, Food processing.
- Thermodynamics
- PENG-ROBINSON
- Components
- fructose, glucose, water
- Unit operations
- SMB
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Read the step-by-step guideReproduce this exact result from Python — the real client.get_example() → run_and_wait() path, not a mockup.
from flowsim.sdk import FlowSimClient
client = FlowSimClient()
example = client.get_example("hfcs-smb-separation")
sim = client.create_simulation(example["title"], example["flowsheet"])
result = client.run_and_wait(sim["id"])
print(result["status"]) # "converged"
streams = client.streams(sim["id"])Related models
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